Friday, January 29, 2016, 7:47 AM
A vaccine for the Zika virus, which has been linked to severe birth defects in thousands of infants, could be ready for emergency use before year-end, one of its lead developers said on Thursday, a timetable well ahead of estimates by U.S. officials.
Canadian scientist Gary Kobinger, part of a consortium working on the vaccine, told Reuters in an interview that the first stage of testing on humans could begin as early as August. If successful, that may allow the vaccine to be used during a public health emergency, in October or November.
“The first thing is to be ready for the worst,” Kobinger, who helped develop a trial vaccine that was successful in fighting Ebola in Guinea, said. “This vaccine is easy to produce. It could be cranked to very high levels in a really short time.” He did not say when it could be widely available.
Jaqueline Vieir (left) watches as her 3-month-old son Daniel, who was born with microcephaly, undergoes physical therapy in Recife, Brazil, on Thursday. Brazilian officials still say they believe there’s a sharp increase in cases of microcephaly and strongly suspect the Zika virus, which first appeared in the country last year, is to blame.
The U.S. has two potential candidates for a Zika vaccine and may begin clinical trials in people by the end of this year, but there will not be a widely available vaccine for several years, U.S. officials said on Thursday.
The mosquito-transmitted virus has been linked to brain damage in thousands of babies in Brazil. There is no proven vaccine or treatment for Zika, a close cousin of dengue and chikungunya, which causes mild fever and rash. An estimated 80% of people infected have no symptoms, making it difficult for pregnant women to know whether they have been infected.
In Geneva, the World Health Organization said on Thursday that Zika is spreading “explosively” and could affect as many as four million people in the Americas.
A government campaign poster warns about Zika virus symptoms in the maternity ward in Guatemala on Thursday.
Kobinger, the lead scientist on this project from Quebec City’s Laval University and head of special pathogens at Canada’s National Microbiology Laboratory in Winnipeg, is working with the University of Pennsylvania, led by scientist David Weiner, Inovio Pharmaceuticals and South Korea’s GeneOne Life Science.
Joseph Kim, chief executive of Inovio, said the timeline to make the vaccine available by year’s end is aggressive, but possible.
A sterile female Aedes aegypti mosquito is seen on the forearm of a health technician in a research area to prevent the spread of Zika virus and other mosquito-borne diseases in Guatemala City.
“I believe this will be the first to go into human testing. We believe we’re ahead of the pack in the race for a Zika vaccine,” he said in an interview.
Inovio shares on the Nasdaq jumped 7.6% on Thursday to close at $ 5.78.
Other vaccine candidates appear to be moving more slowly.
A Health Ministry employee fumigates against Aedes Aegypti mosquito, at a home in Caracas on Friday. Venezuela has recorded 4,700 suspected cases of people infected by the Zika virus, which is thought to cause brain damage in babies.
The Sao Paulo-based Butantan Institute said last week it planned to develop a vaccine “in record time,” although its director warned this was still likely to take three to five years.
The candidate vaccine Kobinger is working on mimics the virus, triggering the body’s immune system, he said.
“When the real thing comes in, then the antibodies are there, the immune system is primed, it’s ready to attack right away,” Kobinger said.